What is the focus of anti-aging?
Aging is an inevitable natural phenomenon and a process that everyone must go through. However, there is a difference in aging: some people go twilight early, and some people move forward courageously in time. Among them, in addition to external stress, genes and other factors that affect the speed of aging, enzymes in the body also play an important role in the aging process, especially "Coenzyme I"-NAD+.
NAD+ is a biochemical substance with a wide range of functions in the human body. It can assist in generating 95% of the human body's energy and participate in more than 50% of the metabolic activities in the human body. At the same time, longevity proteins (Sirtuins), which are responsible for inhibiting aging in the human body, also depend on NAD+ for their activity. It can be seen that NAD+ plays an important role in the process of cell resistance, cell mutation and apoptosis. However, as the age continues to grow, the NAD+ in the human body will also decrease, and the body's functions will gradually decline.
Since the human body needs NAD+, what is the relationship between NMN and NAD+?
NMN (nicotinamide mononucleotide) is the most direct precursor of the cofactor NAD+ of longevity protein in the human body. Due to the large size of NAD+ molecules, it is difficult to penetrate the cell membrane into the cell, so NAD+ cannot be taken up directly. Through the process of "precursor conversion", after the human body takes in NMN, it will be converted into NAD+ in the body, thereby increasing the level of NAD+ in the body and achieving anti-aging effects.
Is NMN reliable?
According to Harvard University professor David Sinclair's NMN experiment: After a week of ingestion of NMN, the muscle activity of 2-year-old experimental mice returned to the level of 6 months, which is equivalent to the 60-year-old returning to 20 years old, and the final life span is extended by 20 %; NASA also began to study the effect of NMN on DNA repair in 2017, because the DNA damage caused by high-energy particle radiation in space to astronauts can cause 5% of the body’s cell death and significant aging, and NMN is a solution to this The problem brings hope. Therefore, the efficacy of NMN is recognized by the scientific community.
The practical utility of NMN
After oral administration, NMN can effectively and quickly enter the bloodstream within 10 minutes, and after 30 minutes it is absorbed by body organs and converted into NAD+, and exerts effects on different body tissues, producing the following effects:
- Catalyzes more than 95% of the energy required for life activities
The mitochondria in human cells are the cell’s power plant, and NAD+ is an important coenzyme in the mitochondria for aerobic oxidation and metabolism of the tricarboxylic acid cycle to generate the energy molecule ATP. Become the energy needed by the human body.
- Repair genetic genes (DNA)
NAD+ is used as a substrate to transform and generate gene repair enzyme-PARP1. At the same time, PARP1, which has been inactivated by protein binding, can be isolated to restore its activity. PARP1 can recode damaged genes according to the normal gene sequence, so as to achieve the effect of repairing genes.
NAD+ plays a role in maintaining the chemical communication between the nucleus and mitochondria. If this communication is weakened, it will lead to the decline of mitochondria, and the decline of mitochondria is an important cause of cell aging, so supplementing NAD+ can enhance communication and slow down the process of cell aging.
- Maintain muscle growth
Muscle cells release growth factors when they exercise, and capillary epidermal cells receive growth factors to accelerate their growth. This process depends on the longevity protein Sirtuin1 produced by NAD+. The less NAD+ content in the body, the worse the effect of exercise to stimulate muscle growth.
- Alcohol metabolism
Alcohol metabolism is divided into two steps. First, it is converted into toxic acetaldehyde, and then further decomposed into harmless acetic acid. Each step must rely on the catalysis of NAD+.
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