Epigenetics is the key to human longevity?

No one likes aging. Of course, some of us can grow old gracefully, but for many people, this may mean suffering from diseases such as dementia and Alzheimer’s, loss of mobility, and even loss of independence. Self-care ability. However, through the exploration of epigenetics, researchers have found that they can find a way to reverse our biological age-or at least promote long-term health.

To a certain extent, "age depends on our feelings and mood" is right. We have two different ages, the actual age and the biological age. Our actual age refers to the number of years a person has been alive, and our biological age takes many lifestyle factors into account: compare our physical function age with the average health level and health level. Dr. Tom Stubbs, Chief Executive Officer of Chronomics, said: "According to our genes, lifestyle, diet, amount of exercise, and environment, all of us have different rates of physical aging." "Our biological age ultimately determines our lifespan, not our actual age. "

The epigenetic clock developed by Steve Horvath in 2013 is an effective tool that can be used to measure physiological age. It is the most accurate quantitative indicator of physiological age. The epigenetic clock is a mathematical model that predicts aging by measuring the level of DNA methylation in different parts of the genome (a set of genes or genetic material present in a cell). Dr. Stubbs added: "Through the study of DNA methylation to determine the biological age, we hope to find a way to control gene expression, which may be the key to extending human life."

To help us better understand the benefits of the epigenetic clock and biological age, experts have conducted many studies. Daniel Belsky of Duke University in the United States and his team studied 18 types of cellular aging in nearly 1,000 adults. The signs include blood pressure and cardiovascular function. They found that some people’s age is much faster or slower than the actual date of birth indicates, some people’s biological age is 10 years younger than their actual age, and some people are 23 years older than their actual age. Similarly, when James Timmons of King's College London and his team examined the expression of 150 genes related to aging, they found that the biological age is more important than the actual age with Alzheimer’s disease and osteoporosis. The risk of disease is more closely related.

When we find that we are aging much faster than expected and are at risk of serious diseases, knowing our biological age is like giving us a second chance, because we can take measures to reverse epigenetics, such as by adjusting our diet. And increasing the amount of exercise can prevent and reduce the risk of cardiovascular disease. As Horvath said: "This sounds like science fiction, but it is conceptually feasible. All epigenetic marks are reversible, so in theory, it is possible to reset the clock."

Since our diet is a key trigger of epigenetic changes, researchers have been examining whether our food intake also affects DNA methylation. The researchers targeted mice and restricted their food intake to 40% of their age group. They found that the control of dietary restrictions established an epigenetic change in the genes involved, thereby prolonging life span by 30%. The lead author of the study, Dr. Oliver Hahn of the Max Planck Institute’s Institute of Aging Physiology under Partridge Group, said: “Dietary restriction partially prevents age-induced methylation changes and promotes the reprogramming of lipid metabolism genes. To make beneficial changes to help our bodies function better.”

The epigenetic research on mice is still going on in unimaginable areas. I hope that these findings will be compelling enough to prompt similar studies in humans. Since our aging process is much slower than that of mice, we need Study longer. However, researchers at Harvard Medical School believe that they may find the key to rejuvenating youth by reversing vascular aging, which has prompted clinical trials.​​ Researchers have discovered a way to reverse vascular aging (in mice) by increasing the presence of natural molecules in the body, thereby enhancing the physiological response to exercise. In some cases, the exercise capacity of these mice was improved by 56% to 90% compared with the mice receiving the treatment.

Yes, one day, we may really be able to live more years, run a marathon with lungs that feel 10 years younger than our actual age (though our knees may not be too young), and then reverse the deception that was originally brought about by aging The disease-"alive" will surely be encouraging.

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