Patented Caffeine Alternative?

NMN Cell Revival includes a recently granted USA patented ingredient.

enXtra®, a proprietary extract made from the plant from the ginger family: Alpinia galanga, has been granted a US patent for the patent application publication no. US20180221430 A1 based on the granted claims on method of use of Alpinia galanga for improved cognitive performance, mental alertness and sleep quality without side effects such as cardiovascular problems.

This method of use patent covers a formulation of Alpinia galanga for improvement of cognitive performance such as mental alertness and increased attention that has previously been demonstrated in five clinical studies.

The latest human clinical study on Enxtra (A Randomized Placebo Controlled Clinical Trial Demonstrating Safety & Efficacy of EnXtra ® in Healthy Adults - PubMed (nih.gov) showed it could significantly improve alertness by over 100% but did not bring about heart rhythm and sleep disturbances – problems commonly seen in the consumption of caffeine or energy boosting ingredients.
“While caffeine continues to lead in the nootropic space because of its experiential benefits, consumers are constantly looking for better and healthier alternatives.

Caffeine is actually classified as a psychoactive drug

Clinically backed enXtra® provides a novel, natural caffeine alternative for increased alertness and sustained attention and focus.

enXtra® was also recently certified by Informed Ingredient, a Quality Assurance certification for dietary supplement manufacturing facilities, which ensures that ingredients have been tested for banned substances and comply with WADA (World Anti-Doping Agency) guidelines. The certification guarantees that ingredients are manufactured to high quality standards. No other substance were added to this 100% organic ingredient that is derived from a plant extract. It is Health Canada Approved and has US FDA GRAS certification.

The ingredient has been used in energy beverages as in the case of Japan’s Taisho Pharmaceutical Holdings’ Raizin series (Caffeine-free rush: Japan’s Taisho launches first botanical-based energy-boosting beverage (nutraingredients-asia.com). The ingredient also won the Nutraingredients Ingredient of the Year Award (WATCH – NutraIngredients-Asia awards winner Enovate Biolife wants to move beyond sports nutrition (nutraingredients-asia.com)

Alpinia galanga is native to Southeast Asia, where it’s used as a food and herb.[1] It is part of the ginger family, and, similar to ginger, the rhizome, or creeping rootstalk is what’s used. The rhizome has a pungent smell reminiscent of black pepper and pine. The similarity in appearance to the ginger rhizome has led to one of its common names, Thai ginger. In some traditional medical systems, it is regarded as being superior to ginger. EnXtra® is a clinically studied and standardized Alpinia galanga rhizome extract. In humans studies, EnXtra® has been synergistic with caffeine. In a clinical study, supplementation with EnXtra® supported alertness and focus It’s clinically proven to improve alertness and focus for up to 5 hours with and without caffeine. EnXtra® can be used as a replacement for caffeine or used with caffeine to prevent crash and prolong caffeine’s nootropic benefits.

ENXTRA ALPINIA GALANGA KEY MECHANISMS

Cognitive function
• Supports mental alertness
• Supports attention
• Supports memory

Brain function
• Neuroprotective effects
• CNS stimulant activity
• Supports locomotor activity and motor coordination
• Downregulates acetylcholinesterase (AChE) levels/activity in the brain
• Downregulates monoamine oxidase (MAO) A and B levels/activity in the brain

Antioxidant defenses
• Upregulates antioxidant enzymes in the brain (superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx])
• Replenishes glutathione (GSH) levels
• Downregulates lipid peroxidation

Other effects
• Supports healthy cardiometabolic parameters
• Immunostimulant activity

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