We have been plagued by the global coronavirus pandemic for several months. It is uncertain when this will end. Anxiety and the increase in research problems have left us all on the brink. But despite this, all sectors are still working hard to study these problems, hoping to find the most effective solution to cure and prevent COVID-19 infection as soon as possible. In this article, the studies mentioned are all focused on NAD + anti-COVID-19 ability.
What is MTOR?
mTOR, also known as the mammalian target of rapamycin, is a pathway in which biological growth is regulated and the growth is coordinated according to the amount of nutrients. It is also regarded as the main nutritional regulator of animal growth. It plays an important role in metabolism, aging process and common diseases. It plays an important role in the following aspects:
- Cell senescence
- Mitochondrial function
- Autophagy (the ability of cells to reclaim their nutrients)
mTOR was discovered in 1991 by Dr. David Sabatini, a graduate student of the Johns Hopkins School of Medicine. He isolated a then unknown protein that would change his life and the field of science forever. Now it is called mTOR. .
Where is the relationship between MTOR and COVID-19?
In a recent study, scientists confirmed that COVID-19 uses mTOR to initiate its cell growth and replication mechanism. This activity helps the virus produce enough components to increase the likelihood of its successful reproduction.
Due to the emergence of new discoveries about how COVID-19 uses mTOR, experts are trying to find out how to target mTOR, and one of these potentially effective methods is to try to activate the anti-aging protein SIRT1.
COVID-19, SIRT1, and NAD+
Now, what is the connection between the three terms mentioned in this section of the blog? We first define what Sirtuins are.
Sirtuins are a proteome that plays a variety of important roles, but on the whole, they can promote cell health, maintain functional balance and prevent DNA damage. It can also block mTOR, thereby avoiding overgrowth and replication.
For viral infections such as coronaviruses, SIRT1 (also known as NAD-dependent deacetylase Sirtuin-1) is a natural regulator of mTOR, so it can inhibit and slow down the virus' replication intention. In addition, the study also found that all Sirtuins, including SIRT1, have natural antiviral properties.
Raise NAD+ level to activate SIRT1
As mentioned earlier, SIRT1 is in other words the NAD-dependent deacetylase Sirtuin-1. Since the activation of SIRT1 depends on the level of NAD+, if managed correctly, the support of NAD+ and the activation of SIRT1 can help minimize the severity of the disease. The normal NAD+ level can reduce the severity of the immune response of these patients, thereby improving their clinical conditions, especially for elderly patients, because they are greatly affected by COVID-19.
How can I improve my NAD+ level?
You can start to incorporate physical activity into your daily activities in a simple way. This will help you stabilize your NAD+ level. Exercise helps cells burn NADH for energy, thereby producing more NAD. Fasting also helps burn carbohydrates to accumulate NADH and It becomes NAD+. You should also check the daily menu and add healthy foods, especially fruits and fermented foods, such as fish, milk, green vegetables, etc., because they are an important source of NADH and NR, which is the predecessor of NAD+. Finally, increase the intake of NAD supplements or NMN cell regeneration supplements [NMN CELL REVIVAL] to help increase cell energy and achieve a healthy elderly life. You must remember to stay safe at this difficult time.