Fat Shredding Technology
Sinetrol ®, from the French company Fytexia, is a citrus extract standardized in polyphenols helping to reduce the excess of fat mass.
Sinetrol acts by way of the exclusive mechanism of Fat Shredding Technology (FST). Without thermogenic effect, Sinetrol facilitates lipolysis trough the inhibition of phosphodiesterase PDE-4, the enzyme that catalyzes the hydrolysis of cyclic adenosine monophosphate (cAMP). Consequently, higher cAMP levels lead to an increased rate of triglyceride (TG) breakdown. SINETROL is a potent inhibitor of cAMP-phosphodiesterase (PDE) (97%) compared to other purified compounds (cyanidin-3 glycoside, narangin, caffeine). These results suggest that SINETROL has a strong lipolytic effect mediated by cAMP-PDE inhibition. SINETROL may serve to prevent obesity by decreasing BMI. (https://pubmed.ncbi.nlm.nih.gov/18617377/)
It works by stimulating lipolysis, a catabolic process leading to the breakdown of triglycerides stored in the fat cells (adipocytes), releasing free fatty acids (FFA). Sinetrol reduces body fat to help you reach and maintain a healthy body composition.
Clinical studies have been ran on Sinetrol, both supporting the mechanism of action and bringing strong results on weight loss: an average -10% of abdominal fat, -5,15cm of waist circumference, -5,15cm of hip circumference after 3 months, with no change on food intake or physical activity. (https://www.tandfonline.com/doi/abs/10.3109/09637486.2015.1042847?journalCode=iijf20)
In a 12-week, randomized, double-blind, placebo-controlled trial conducted in France (https://pubmed.ncbi.nlm.nih.gov/23554029/), Sinetrol-XPur was given to overweight subjects twice daily with meals in the tested group (Number of subjects = 47) versus a placebo group (Number of subjects = 48).
Waist and hip circumference and abdominal fat were decreased in the Sinetrol-XPur group as compared with the placebo group (p <0.0001) (-5.71% vs. -1.56% for waist, -4.71% vs. -1.35% for hip and- 9.73% vs. -3.18% for fat). Inflammatory markers were reduced (C-reactive protein: -22.87% vs. +61%; fibrinogen: -19.93% vs. -1.61%, p <0.01). Oxidative stress was lowered as seen by the reduction of malondialdehyde (-14.03% vs. 2.76%) and the increase in superoxide dismutase and glutathione (17.38% vs. 2.19% and 4.63% vs. -2.36%, respectively, p <0.01). No adverse effects were observed. Kidney, liver, and lipid panels remained unchanged.
Results indicated that Sinetrol-XPur supplementation is a viable option for reducing abdominal fat, waist and hip circumference, and body weight and for improving inflammatory, glycemic, and oxidative status in healthy overweight individuals.
A second study in Korea investigated the effect of Sinetrol-XPur on weight and body fat reduction in overweight or obese Korean participants (https://pubmed.ncbi.nlm.nih.gov/32130058/).
Among 100 overweight or obese participants enrolled in a 12-week randomized, double-blinded, controlled study, 86 participants completed the trial. Participants took either two Sinetrol-XPur tablets (450 mg per tablet) or two placebo tablets once a day. Bodyweight , body fat percentage, body mass index (BMI), body fat mass, waist circumference, and various safety parameters were measured. After the 12-week intervention, a significant reduction was observed in the body fat mass (P = .030) by dual-energy X-ray absorptiometry (DEXA), body weight (P = .002), and BMI (P = .002) compared to the placebo. Body fat percentage (P = .007) by DEXA showed a significant reduction in the Sinetrol-XPur group, but no difference compared to the control group. Abdominal metabolic risks by computed tomography and blood biochemistry analysis were significantly decreased in the Sinetrol-XPur group, but there were no differences between the Sinetrol-XPur and placebo groups. Safety profiles were not different between the two groups.
These results suggested that Sinetrol-XPur significantly reduced body weight, body fat mass, and BMI in obese Korean subjects, which confirms the antiobesity effect of Sinetrol-XPur in the Korean population.
With several published clinical study, an ex vivo study demonstrating the mechanism of action and a new clinical study (download the Science Pack for more detailed information in English only), Sinetrol, the natural fat shredder, is a safe solution to get rid of the excess of fat mass.
S-CELL's [FAT BUSTER] contains Sinetrol®, plant-based chitin and BioPerine®, which triple strikes to kick away excess fat in your body and help reduce the risk of diseases caused by high fat and cholesterol. Take [FAT BUSTER] with meals , so that you can enjoy luxurious food without worrying about getting fat.